In order to reduce the power consumption of tire monitoring module in the tire pressure monitoring system,adopting the 125 kHz low-frequency wake-up communication link achieve proactive monitoring to reduce tire monitoring module's power consumption to extend the life of lithium batteries.Most of the time,125 kHz lowfrequency wake-up receiver is in monitoring mode,so it is essential to take an low-power design analysis.As for the receiver in 125 kHz low-frequency wake-up communication link,adopting Shanghai ASMC's 0.35μm 5V-40 VBCD automotive electronic technology to design the low-frequency wake-up receiver,total area of the receiver is 1.4mm~2,and core area is 0.48 mm~2.After tapeout and test validation,post-simulation power consumption of the receiver is 4.72μA.Tested Sensitivity is 0.5mVpp,the maximum tested data rate is 35 Kbps,and the receiver can satisfy the tire pressure monitoring system low-frequency wake-up request.