A 10 Mbps OQPSK transceiver working in the 400-450 MHz frequency range is designed for medical telemetry applications requiring wireless communication with both high data rate and low power consumption. An inverter based phase-switching transmitter has been proposed to lower the transmitter power consumption. Moreover, a digital-assisted DC offset calibration (DCOC) technique that combines the PGA-gain-uncorrelated DCOC method and a lookup table is adopted to enable an zero-IF receiver architecture. Fabricated in 65 nm CMOS process, both the transmitter and the receiver consumes ~3 mW from 1 V supply at 10 Mbps data rate. The transceiver energy efficiency is ~0.3 nJ/bit, which outperforms the similar designs in recent literature.