A system architecture for the lifetime recording of human being pathological features is proposed. The system is composed of a potable base station (PBS), a wireless intelligent sensing/intervention devices (SID) as well as a remote data center for data processing and storage. An intelligent body sound sensor is chosen for discussion for the reason that some key pathological features could be reflected by human body sounds, such as the cardiopulmonary tones, the bowel sounds as well as the fetal heart sounds. The design considerations of PBS with a dedicated monolithic transceiver are addressed for the communication between PBS and SID. A application prototype using the proposed technology for tracing the fetal heart rate by monitoring a pregnant woman is presented.