This paper proposes an architecture of the wireless endoscopy system for the diagnoses of whole human digestive tract and real-time endoscopic image monitoring. The low-power digital IC design inside the wireless endoscopic capsule is discussed in detail. A very large scale integration (VLSI) architecture of three-stage clock management is applied, which can save 46% power inside the capsule compared with the design without such a low-power design. A stoppable ring crystal oscillator with minimal overhead is used in the sleep mode, which results in about 60-muW system power dissipation in sleep mode. A new image compression algorithm based on Bayer image format and its corresponding VLSI architecture are both proposed for low-power, high-data volume. Thus, 8 frames per second with 320*288 pixels can be transmitted with 2 Mb/s. The digital IC design also assures that the capsule has many flexible and useful functions for clinical application. The digital circuits were verified on field-programmable gate arrays and have been implemented in 0.18-mum CMOS process with 6.2 mW